The Backbone Boilerplate is a popular open source project that I created in order to push the limits of what defines modern web development. With scaffolding and built in build tasks that take care of minification, concatentation, server, template compilation, etc. it is an obvious choice for beginner to advanced developers. It fully integrates the AMD pattern and the RequireJS loader as well as swapping out for an AMD shim during production.
This is by far the most sophisticated client side development platform available today, and while it is not perfect, it will certainly push other developers to create similar packages for Ember.js, Knockout.js, etc.
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