Translating ErbB receptor story into clinics: a structural pathology approach

A session at JCUP IV

  • Gloria Fuentes

Thursday 6th June, 2013

4:45pm to 5:15pm (CJT)

The ErbB family of receptors have been related to different types of cancers. A growing body of data from genetics, cellular biology, biochemistry, structural and computational biology has led to substantial progress in understanding the mechanisms of ErbB regulation.

We used structural and molecular modeling techniques to examine the molecular synergistic effect of several antibodies blocking ErbB2 function.

Recently we focused on exploiting EGFR structural biology to understanding acquired resistance. Drugs that competitively replace a natural substrate become ineffective by mutations that reduce the drug's affinity relative to that of the natural substrate. Understanding the underlying mechanisms is of utmost importance in efforts to design new drugs targeting mutant proteins.

We have modeled this emergence in EGFR and ErbB2 after treatment with lapatinib, by investigating the structural, dynamic and energetic effects on these kinases. The study reveals binding modes and subpopulations that are presumably normally cryptic.

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Gloria Fuentes

Next session in Ohtemachi SunSky Room

5:15pm Enabling the Best Structure-Based Design Engine: an Expert Scientist by Jeff Blaney

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Japan Japan, Tokyo

6th7th June 2013

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Time 4:45pm5:15pm CJT

Date Thu 6th June 2013


Ohtemachi SunSky Room, Asahi Seimei Ohtemachi Building

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